The study, began in 2003, included only the most severely affected patients (those in the New York Heart Association class III or IV). In addition to their regular medication, study subjects were randomly assigned to receive either 100 mg of CoQ10 or placebo (blank pill) 3 times daily. Each patient was followed up with a wide variety of outcomes measures for two years. The study showed that even in patients with the most severe classes of heart failure, CoQ10 supplementation restored deficient CoQ10 levels, extending life span and improving quality of life.
But the study’s main endpoint measurement was the most dramatic indicator of success. Only 14% of patients in the supplemented group had a major adverse cardiac event. The results of this study highlights the importance of regular CoQ10 supplementation for anyone with heart failure or its risk factors, such as endothelial dysfunction, hypertension, or family history of heart attacked. Studies have shown that CoQ10 improves each of these risk factors for heart failure.